Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:3014371 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
301437130152558852-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
301535230164971146glycerate kinaseQuickGO ontologyBLASTP
30165903016890301Bacterial RNase P class AQuickGO ontologyBLASTP
30183583018861504IS1 transposase orfBQuickGO ontologyBLASTP
30189363019244309putative IS1 encoded proteinQuickGO ontologyBLASTP
30195363019754219threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
30200693021007939transcriptional regulator TdcAQuickGO ontologyBLASTP
30211063022095990threonine dehydratase catabolicQuickGO ontologyBLASTP
302211730234481332threonineserine transporterQuickGO ontologyBLASTP
302347430246821209propionate kinaseQuickGO ontologyBLASTP
302471630270102295formate acetyltransferaseQuickGO ontologyBLASTP
30270243027413390putative endoribonuclease L-PSPQuickGO ontologyBLASTP
302748530288491365L-serine ammonia-lyase TdcGQuickGO ontologyBLASTP
30291403029643504IS1 transposase orfBQuickGO ontologyBLASTP
30297183029966249transposaseQuickGO ontologyBLASTP
302990030312311332serine transporter family proteinQuickGO ontologyBLASTP
303125930325691311hypothetical proteinBLASTP