Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:2529033 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25290332529536504IS1 transposase orfBQuickGO ontologyBLASTP
25296112530024414transposaseQuickGO ontologyBLASTP
25302062530961756lipoprotein VacJ familyQuickGO ontologyBLASTP
25312552532187933hypothetical proteinBLASTP
2532262253233877tRNA-ArgQuickGO ontology
25323422532500159hypothetical protein
25336102533912303IS911 transposase orfAQuickGO ontologyBLASTP
253395925352271269D-serine ammonia-lyaseQuickGO ontologyBLASTP
253533525368731539multidrug resistance protein YQuickGO ontologyBLASTP
253687325380361164drug resistance MFS transporter membrane fusion protein MFP subunit EmrKQuickGO ontologyBLASTP
25384522539066615positive transcription regulator EvgAQuickGO ontologyBLASTP
253907125426643594sensor histidine kinaseresponse regulator EvgSQuickGO ontologyBLASTP
254272025438651146CAIBBAIF family proteinQuickGO ontologyBLASTP
25439392544883945transporter auxin efflux carrier family proteinQuickGO ontologyBLASTP
254495325466471695oxalyl-CoA decarboxylaseQuickGO ontologyBLASTP
254670125479511251formyl-CoA transferaseQuickGO ontologyBLASTP
25484642549096633hypothetical proteinBLASTP
25497442549986243hypothetical proteinBLASTP
25503392551259921lipid A biosynthesis lauroyl acyltransferase family proteinQuickGO ontologyBLASTP
25515702551686117hypothetical proteinBLASTP
255175125529891239aminotransferase classes I and IIQuickGO ontologyBLASTP
255338425550631680sensor histidine kinaseQuickGO ontologyBLASTP
25550782555812735response regulatorQuickGO ontologyBLASTP