Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:1933605 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
193360519354161812phosphogluconate dehydrataseQuickGO ontologyBLASTP
193565119371261476glucose-6-phosphate 1-dehydrogenaseQuickGO ontologyBLASTP
19372921937441150hypothetical proteinBLASTP
19374641938333870transcriptional regulator rpiR familyQuickGO ontologyBLASTP
193846119399031443pyruvate kinase IIQuickGO ontologyBLASTP
19400401940945906IS2 transposase orfBQuickGO ontologyBLASTP
19412251941428204nitrite extrusion protein 2QuickGO ontologyBLASTP
194237019436591290maltosemaltodextrin ABC transporter permease protein MalFQuickGO ontologyBLASTP
194366219448941233maltosemaltodextrin-binding periplasmic protein MalEQuickGO ontologyBLASTP
19462221947178957UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase homologQuickGO ontologyBLASTP
19473861947847462glycosidaseQuickGO ontologyBLASTP
19479301948205276ABC ATPaseQuickGO ontologyBLASTP
19482571948565309transposase familyQuickGO ontologyBLASTP
194945219510051554IS66 family element transposaseQuickGO ontologyBLASTP
19511081951926819ISSd1 transposase orfBQuickGO ontologyBLASTP
19521231953028906IS2 transposase orfBQuickGO ontologyBLASTP
1956036195611479tRNA-ArgQuickGO ontology
1956126195620479tRNA-OTHERQuickGO ontology
1956211195628676tRNA-MetQuickGO ontologyBLASTP
195633619573851050DNA methylaseQuickGO ontologyBLASTP
19575361957820285hypothetical proteinBLASTP
19579491958329381phage antitermination Q type 1 familyQuickGO ontologyBLASTP
19583471959336990hypothetical proteinBLASTP
19593441960153810KilA-N domain familyQuickGO ontologyBLASTP