Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:1772994 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17738841774414531phage tail protein IQuickGO ontologyBLASTP
177441717761291713gpHQuickGO ontologyBLASTP
17765001776877378IS1 transposase orfBQuickGO ontologyBLASTP
177735417785381185phage tail sheath proteinQuickGO ontologyBLASTP
17785181778649132hypothetical protein
178005417831733120hypothetical proteinBLASTP
17835161784421906IS2 transposase orfBQuickGO ontologyBLASTP
17846971784843147nitrite extrusion protein 2QuickGO ontologyBLASTP
17850921785232141hypothetical proteinBLASTP
178565117868471197transposaseQuickGO ontologyBLASTP
17869861787285300integration host factor alpha subunitQuickGO ontologyBLASTP
178729017896772388phenylalanyl-tRNA synthetase beta-subunitQuickGO ontologyBLASTP
17896921790675984phenylalanyl-tRNA synthetase alpha subunitQuickGO ontologyBLASTP
17908641790998135hypothetical protein
17911251791481357ribosomal protein L20QuickGO ontologyBLASTP
17915341791731198ribosomal protein L35QuickGO ontologyBLASTP
17918281792262435translation initiation factor IF-3QuickGO ontologyBLASTP
179237417943021929threonyl-tRNA synthetaseQuickGO ontologyBLASTP