Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:1593137 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
159313715946721536glutamategamma aminobutyrate antiporterQuickGO ontologyBLASTP
159482815962281401glutamate decarboxylase GadBQuickGO ontologyBLASTP
15963471596460114hypothetical proteinBLASTP
159659015993732784peptidase M16B familyQuickGO ontologyBLASTP
159943016018022373TonB-dependent receptorQuickGO ontologyBLASTP
160184016035251686inner membrane ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
16038161604460645radical SAM domain proteinQuickGO ontologyBLASTP
16044651605226762transcriptional regulator AraC familyQuickGO ontologyBLASTP
160574616080252280molybdopterin oxidoreductase alpha subunitQuickGO ontologyBLASTP
16083591608538180protein FimHQuickGO ontologyBLASTP
16088941609424531protein HipAQuickGO ontologyBLASTP
16102501611155906IS2 transposase orfBQuickGO ontologyBLASTP