Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:1193225 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
119322511946851461sensor histidine kinase PhoQQuickGO ontologyBLASTP
11946851195356672DNA-binding response regulator PhoPQuickGO ontologyBLASTP
119552411968941371adenylosuccinate lyaseQuickGO ontologyBLASTP
11968981197539642hypothetical proteinBLASTP
119757511986811107tRNA 5-methylaminomethyl-2-thiouridylate-methyltransferaseQuickGO ontologyBLASTP
11987351199196462hydrolase NUDIX familyQuickGO ontologyBLASTP
11992061199859654ribosomal large subunit pseudouridine synthase EQuickGO ontologyBLASTP
11999471200060114hypothetical proteinBLASTP
120003112012811251isocitrate dehydrogenase NADP-dependentQuickGO ontologyBLASTP
12023651202769405hypothetical proteinBLASTP
12029901203721732transcriptional regulator mlrAQuickGO ontologyBLASTP
12050641205567504IS1 transposase orfBQuickGO ontologyBLASTP
12056421205896255putative IS1 encoded proteinQuickGO ontologyBLASTP
12069441207849906IS2 transposase orfBQuickGO ontologyBLASTP
12099041210233330hypothetical proteinBLASTP
12102431210587345hypothetical proteinBLASTP
12110091211128120hypothetical proteinBLASTP
12116071211873267cell division topological specificity factor MinEQuickGO ontologyBLASTP
12118771212689813septum site-determining protein MinDQuickGO ontologyBLASTP
12127131213423711septum site-determining protein MinCQuickGO ontologyBLASTP
12139281214296369putative fels-1 Prophage ProteinQuickGO ontologyBLASTP
12142761214500225putative IS1 encoded proteinQuickGO ontologyBLASTP
12145751215078504IS1 transposase orfBQuickGO ontologyBLASTP
12155571215682126hypothetical protein
12156871215980294hypothetical proteinBLASTP
12160521216711660fumarylacetoacetate hydrolase family proteinQuickGO ontologyBLASTP