Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:1090104 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
109010410915821479polysaccharide biosynthesis protein WzxCQuickGO ontologyBLASTP
109185810931381281colanic acid biosynthesis protein WcaKQuickGO ontologyBLASTP
109313510943551221colanic acid biosynthesis glycosyl transferase WcaLQuickGO ontologyBLASTP
109436610957601395colanic acid biosynthesis protein WcaMQuickGO ontologyBLASTP
10959181096913996UDP-N-acetylglucosamine 4-epimeraseQuickGO ontologyBLASTP
10971561098049894regulatory protein GalFQuickGO ontologyBLASTP
109842110995061086dTDP-glucose 46-dehydrataseQuickGO ontologyBLASTP
10995061100405900dTDP-4-dehydrorhamnose reductaseQuickGO ontologyBLASTP
11004631101341879glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
11013461101903558dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
110324611044631218WzxQuickGO ontologyBLASTP
110447911055641086WbwXQuickGO ontologyBLASTP
110561211067571146WzyQuickGO ontology
11067171107664948WbwYQuickGO ontologyBLASTP
110766111087701110WbwZQuickGO ontologyBLASTP
1108857111026314076-phosphogluconate dehydrogenase decarboxylatingQuickGO ontologyBLASTP
111051211116781167UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
111174411127481005NAD dependent epimerasedehydratase familyQuickGO ontologyBLASTP
111311711141511035chain length determinant proteinQuickGO ontologyBLASTP
11142481114859612phosphoribosyl-AMP cyclohydrolasephosphoribosyl-ATP pyrophosphataseQuickGO ontologyBLASTP
11148531115629777imidazoleglycerol phosphate synthase cyclase subunitQuickGO ontologyBLASTP
11156111116348738phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseQuickGO ontologyBLASTP
11163481116938591imidazole glycerol phosphate synthase glutamine amidotransferase subunitQuickGO ontologyBLASTP
111693811180051068histidinol-phosphataseimidazoleglycerol- phosphate dehydrataseQuickGO ontologyBLASTP
111800511190751071histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
111907211203761305histidinol dehydrogenaseQuickGO ontologyBLASTP
11203821121281900ATP phosphoribosyltransferaseQuickGO ontologyBLASTP