Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:725312 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7253127260647534Fe-4S ferredoxin iron-sulfur binding domain proteinQuickGO ontologyBLASTP
726417726872456transcriptional regulator LytR familyQuickGO ontologyBLASTP
726874727572699hypothetical protein
727707727907201hypothetical protein
728120729007888transcriptional regulator AraC familyQuickGO ontologyBLASTP
729436730347912CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
730360730752393DNA-binding proteinQuickGO ontologyBLASTP
7313507324891140putative lipoproteinQuickGO ontologyBLASTP
7326867337801095putative lipoproteinQuickGO ontologyBLASTP
733955734638684DNA-binding response regulatorQuickGO ontologyBLASTP
7346437360641422sensor histidine kinaseQuickGO ontologyBLASTP
736105736938834acetyltransferase gnat familyQuickGO ontologyBLASTP
737011737145135hypothetical protein
737261737977717D-alanyl-D-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
737998738690693DNA-binding response regulatorQuickGO ontologyBLASTP
7387197398011083sensor histidine kinaseQuickGO ontologyBLASTP
7399617411001140hypothetical proteinBLASTP
741243742055813response regulatorQuickGO ontologyBLASTP
7420527433501299sensor histidine kinaseQuickGO ontologyBLASTP
7437457449051161rod shape-determining protein RodAQuickGO ontologyBLASTP
744921745067147hypothetical protein
7450847462621179cyclopropane-fatty-acyl-phospholipid synthaseQuickGO ontologyBLASTP
7465907476211032hypothetical protein
7477927494711680putative ABC transporter ATP-binding proteinpermease proteinQuickGO ontologyBLASTP