Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3753875 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37538753754552678putative transaldolaseQuickGO ontologyBLASTP
37545713755218648haloacid dehalogenase IA family proteinQuickGO ontologyBLASTP
37552423756027786sorbitol-6-phosphate 2-dehydrogenaseQuickGO ontologyBLASTP
37560473756412366PTS system glucitolsorbitol-specific IIA componentQuickGO ontologyBLASTP
375657837575821005PTS system glucitolsorbitol-specific IIBC componentQuickGO ontologyBLASTP
37575953758140546PTS system glucitolsorbitol-specific IIC componentQuickGO ontologyBLASTP
37581853758580396glucitol operon activator proteinQuickGO ontologyBLASTP
375859437596431050putative L-iditol 2-dehydrogenaseQuickGO ontologyBLASTP
37596783760649972putative glucitol operon regulatorQuickGO ontologyBLASTP
376100537623541350phosphoglucosamine mutaseQuickGO ontologyBLASTP
376248937630195312-oxoacidacceptor oxidoreductase gamma subunit pyruvate2-ketoisovalerate familyQuickGO ontologyBLASTP
37630213763770750putative 2-oxoacidacceptor oxidoreductase beta subunitQuickGO ontologyBLASTP
376377037648401071putative 2-oxoacidacceptor oxidoreductase alpha subunitQuickGO ontologyBLASTP
37648563765065210putative 2-oxoacidacceptor oxidoreductase delta subunitQuickGO ontologyBLASTP
37651673765829663hypothetical proteinBLASTP
376609237671621071butyrate kinaseQuickGO ontologyBLASTP
37671913768102912phosphate butyryltransferaseQuickGO ontologyBLASTP
376809537691891095butyrate kinaseQuickGO ontologyBLASTP
376929037708881599oxidoreductase FAD-bindingQuickGO ontologyBLASTP
377089037721701281hypothetical proteinBLASTP
37721403772988849conserved hypothetical protein TIGR00159QuickGO ontologyBLASTP