Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3204480 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
32044803205178699diacylglycerol kinasePAP2 family proteinQuickGO ontologyBLASTP
32052193205719501conserved hypothetical protein TIGR00043QuickGO ontologyBLASTP
320571632078032088putative hydrolaseQuickGO ontologyBLASTP
320782632089861161putative stage IV sporulation proteinQuickGO ontologyBLASTP
32089763209272297sporulation protein YqfCQuickGO ontologyBLASTP
32093863209832447GatBYqey domain proteinQuickGO ontologyBLASTP
32098753210051177ribosomal protein S21QuickGO ontologyBLASTP
32101883210532345HIT family proteinQuickGO ontologyBLASTP
321058932118871299RNA modification enzyme MiaB familyQuickGO ontologyBLASTP
32118873212645759conserved hypothetical protein TIGR00046QuickGO ontologyBLASTP
32127433213681939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
321398932151341146chaperone protein DnaJQuickGO ontologyBLASTP
321527732171481872chaperone protein DnaKQuickGO ontologyBLASTP
32172033217847645co-chaperone GrpEQuickGO ontologyBLASTP
321787432189051032heat-inducible transcriptional repressor HrcAQuickGO ontologyBLASTP
321910632202481143putative oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
322027432220821809GTP-binding protein LepAQuickGO ontologyBLASTP
32222233222618396hypothetical proteinBLASTP
322268932237801092stage II sporulation proteinQuickGO ontologyBLASTP