Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2937981 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
293798129396841704hypothetical proteinBLASTP
293970929416281920glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
29419122942751840flagellinQuickGO ontologyBLASTP
29429662943805840flagellinQuickGO ontologyBLASTP
29439552944296342hypothetical proteinBLASTP
294432329467582436Flagellar hook-associated protein 2QuickGO ontologyBLASTP
29468122947201390flagellar protein FliSQuickGO ontologyBLASTP
29472382947537300hypothetical proteinBLASTP
29475942947950357flaG family proteinQuickGO ontologyBLASTP
29479662948184219carbon storage regulatorQuickGO ontologyBLASTP
29481842948615432hypothetical proteinBLASTP
29486832949645963flagellar hook-associated protein 3QuickGO ontologyBLASTP
294966329515281866flagellar hook-associated protein FlgKQuickGO ontologyBLASTP
29518092952213405flgN family proteinQuickGO ontologyBLASTP
29522132952494282regulator of flagellin synthesis FlgMQuickGO ontologyBLASTP
295308429542441161flagellar motor switch protein FliNQuickGO ontologyBLASTP
29542372955232996flagellar motor switch protein FliMQuickGO ontologyBLASTP
29552602955655396putative chemotaxis protein CheWQuickGO ontologyBLASTP
29557552956114360chemotaxis protein CheYQuickGO ontologyBLASTP
29561422956741600chemotaxis protein CheCQuickGO ontologyBLASTP
295676729588422076chemotaxis protein CheAQuickGO ontologyBLASTP
29588552959625771chemotaxis protein methyltransferase CheRQuickGO ontologyBLASTP
295964029607041065protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
29607272961215489chemotaxis protein CheDQuickGO ontologyBLASTP
29612322961678447chemotaxis protein CheWQuickGO ontologyBLASTP
296169429637272034hypothetical proteinBLASTP
296398029659351956PTS system glucose family IIABC componentQuickGO ontologyBLASTP