Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2860960 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
286096028627891830flagellar biosynthetic protein FliRFlhBQuickGO ontologyBLASTP
28628232863092270flagellar biosynthesis protein FliQQuickGO ontologyBLASTP
28631042863880777flagellar biosynthetic protein FliPQuickGO ontologyBLASTP
28638642864271408flagellar biosynthesis domain proteinQuickGO ontologyBLASTP
28643442864865522flagellar basal body-associated protein FliLQuickGO ontologyBLASTP
28648622865605744chemotaxis motB proteinQuickGO ontologyBLASTP
28655982866410813chemotaxis MotA proteinQuickGO ontologyBLASTP
28664072866616210flagellar protein FlbDQuickGO ontologyBLASTP
286685028678871038flagellar hook protein flgEQuickGO ontologyBLASTP
28679692868388420flagellar operon proteinQuickGO ontologyBLASTP
28684032869200798flagellar hook capping proteinQuickGO ontologyBLASTP
286923028706181389flagellar hook-length control proteinQuickGO ontologyBLASTP
28706242871061438flagellar protein FliJQuickGO ontologyBLASTP
287116728724831317flagellar protein export ATPase FliIQuickGO ontologyBLASTP
28725232873311789flagellar assembly protein FliHQuickGO ontologyBLASTP
287329528743081014flagellar motor switch protein fliGQuickGO ontologyBLASTP
287431528758951581flagellar M-ring protein fliFQuickGO ontologyBLASTP
28759112876225315flagellar hook-basal body complex protein FliEQuickGO ontologyBLASTP
28767682877169402flagellar basal-body rod protein FlgBQuickGO ontologyBLASTP
28777422878596855flagellinQuickGO ontologyBLASTP
28787412879109369hypothetical proteinBLASTP
287964928809711323argininosuccinate lyaseQuickGO ontologyBLASTP