Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2635750 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
263575026372731524Mg chelatase homologQuickGO ontologyBLASTP
26372892637660372conserved hypothetical protein TIGR00252QuickGO ontologyBLASTP
26380272638836810ribonuclease HIIQuickGO ontologyBLASTP
26391332640011879GTP-binding proteinQuickGO ontologyBLASTP
26403162640840525signal peptidase IQuickGO ontologyBLASTP
26408992641243345ribosomal protein L19QuickGO ontologyBLASTP
26413952642117723tRNA guanine-N1-methyltransferaseQuickGO ontologyBLASTP
2642108264260249516S rRNA processing protein RimMQuickGO ontologyBLASTP
26427152642942228hypothetical proteinBLASTP
26429632643211249ribosomal protein S16QuickGO ontologyBLASTP
264324226445911350signal recognition particle proteinQuickGO ontologyBLASTP
26446042644936333DNA-binding proteinQuickGO ontologyBLASTP
26451602646071912signal recognition particle-docking protein FtsYQuickGO ontologyBLASTP
264623426498153582chromosome segregation protein SMCQuickGO ontologyBLASTP
265007426511651092radical SAM domain proteinQuickGO ontologyBLASTP
26511582651862705ribonuclease IIIQuickGO ontologyBLASTP
26519882652221234acyl carrier proteinQuickGO ontologyBLASTP
265229926533061008fatty acidphospholipid synthesis protein PlsXQuickGO ontologyBLASTP
26533962653578183ribosomal protein L32 family proteinQuickGO ontologyBLASTP
26535922654092501ribosomal protein L32 family proteinQuickGO ontologyBLASTP
265421026554031194acetate kinaseQuickGO ontologyBLASTP
26555432656541999phosphate acetyltransferaseQuickGO ontologyBLASTP