Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2171584 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
217158421734461863ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
217344321757432301putative ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
21761592176602444transcriptional regulator MarR familyQuickGO ontologyBLASTP
21767142177154441sperminespermidine acetyltransferaseQuickGO ontologyBLASTP
21773862178069684molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
21780712178298228molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
217868121804981818aldehyde ferredoxin oxidoreductase tungsten-containingQuickGO ontologyBLASTP
218090521828001896aor transcriptional regulatorQuickGO ontologyBLASTP
21828492183289441MOSC domain proteinQuickGO ontologyBLASTP
21832912183770480molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
21837742184733960molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
218479221866961905molybdopterin biosynthesis enzyme MoeA putative molybdate binding domainQuickGO ontologyBLASTP
218670821879341227molybdopterin biosynthesis enzyme MoeAQuickGO ontologyBLASTP
21879582188446489molybdopterin biosynthesis enzyme MogQuickGO ontologyBLASTP
21886542189346693tungstate ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
21893432190014672tungstate ABC transporter permease proteinQuickGO ontologyBLASTP
21900232190874852tungstate ABC transporter tungstate-binding proteinQuickGO ontologyBLASTP
219109321924151323MATE efflux family proteinQuickGO ontologyBLASTP
21924082192611204hypothetical proteinBLASTP
21928522193496645hypothetical proteinBLASTP
21938192194490672ABC transporter ATP-binding proteinQuickGO ontologyBLASTP