Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:2061502 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20615022062116615hypothetical proteinBLASTP
20633342064155822sporulation transcription factor Spo0AQuickGO ontologyBLASTP
206458420658101227stage IV sporulation protein BQuickGO ontologyBLASTP
20662322067128897homoserine O-succinyltransferaseQuickGO ontologyBLASTP
206715520683811227homoserine dehydrogenaseQuickGO ontologyBLASTP
206842120697011281O-acetylhomoserine aminocarboxypropyltransferasecysteine synthase family proteinQuickGO ontologyBLASTP
207000020717031704DNA repair protein recNQuickGO ontologyBLASTP
20717162072168453arginine repressorQuickGO ontologyBLASTP
20721702073015846ATP-NAD kinaseQuickGO ontologyBLASTP
20730152073836822hemolysin AQuickGO ontologyBLASTP
2073858207572618691-deoxy-D-xylulose-5-phosphate synthaseQuickGO ontologyBLASTP
20757272076296570hypothetical proteinBLASTP
20770992077971873geranyltranstransferaseQuickGO ontologyBLASTP
20780962078311216exodeoxyribonuclease VII small subunitQuickGO ontologyBLASTP
207840520796101206exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
20796812080106426N utilization substance protein BQuickGO ontologyBLASTP
20802452080640396alkaline shock proteinQuickGO ontologyBLASTP
20807222081246525stage III sporulation protein AHQuickGO ontologyBLASTP
20813082081904597stage III sporulation protein AGQuickGO ontologyBLASTP
20820432082633591stage III sporulation protein AFQuickGO ontologyBLASTP
208266920838321164stage III sporulation protein AEQuickGO ontologyBLASTP
20838412084224384stage III sporulation protein ADQuickGO ontologyBLASTP