Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:1614333 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
161433316163452013putative ATP-dependent DNA helicase PcrAQuickGO ontologyBLASTP
16163991617361963XerCD integrase-recombinase proteinQuickGO ontologyBLASTP
16175291617831303hypothetical proteinBLASTP
161830516194831179divergent AAA domain familyQuickGO ontologyBLASTP
161962416210451422type I restriction enzyme r protein n terminus hsdr_nQuickGO ontologyBLASTP
16211681621371204hypothetical proteinBLASTP
16216511621956306hypothetical proteinBLASTP
16219491622107159hypothetical proteinBLASTP
16222401622896657DNA-binding proteinQuickGO ontologyBLASTP
16233621623520159hypothetical proteinBLASTP
162356716250721506hypothetical proteinBLASTP
162516916285463378hypothetical protein
16286611628837177meprin and traf homology domain-containing proteinQuickGO ontology
162886216310482187hypothetical proteinBLASTP
16313511632112762hypothetical protein
16321841632882699hypothetical protein
16331781633693516endonuclease domain proteinQuickGO ontology
16337531633995243hypothetical proteinBLASTP
16340231634211189hypothetical protein
16342841634496213hypothetical proteinBLASTP
16345651634747183hypothetical proteinBLASTP
16348721635117246hypothetical proteinBLASTP
16352371635719483hypothetical protein
16357681636349582hypothetical protein
16365831637026444hypothetical proteinBLASTP
16371721637657486phage terminase P27 familyQuickGO ontologyBLASTP
163765416393451692putative phage terminase large subunitQuickGO ontologyBLASTP
16393691639551183hypothetical proteinBLASTP
163959516408451251phage portal protein HK97 familyQuickGO ontologyBLASTP
16410001641563564prophage LambdaBa02 Clp protease family proteinQuickGO ontologyBLASTP
164163716428691233phage major capsid protein HK97 familyQuickGO ontologyBLASTP
16429531643246294phage protein phi-105 familyQuickGO ontologyBLASTP
16432361643604369putative phage head-tail adaptorQuickGO ontologyBLASTP
16436051643964360phage protein HK97 gp10 familyQuickGO ontologyBLASTP
16439801644336357hypothetical proteinBLASTP
16443991644980582phage major tail protein Phi13 family subfamilyQuickGO ontologyBLASTP
16450381645430393hypothetical proteinBLASTP
16455441645663120hypothetical protein