Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:1427981 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14279811428127147hypothetical protein
14289241429181258hypothetical proteinBLASTP
14294651430211747putative lipoproteinQuickGO ontologyBLASTP
14305291430756228rubredoxinQuickGO ontologyBLASTP
143078814322481461putative glyceraldehyde-3-phosphate dehydrogenase NADP-dependentQuickGO ontologyBLASTP
14322881433229942putative thioredoxin reductaseQuickGO ontologyBLASTP
14339901434367378GrdX proteinQuickGO ontologyBLASTP
143445814357441287glycine reductase complex component B alpha and beta subunitsQuickGO ontologyBLASTP
143577714370781302glycine reductase complex component B gamma subunit selenocysteine-containingQuickGO ontologyBLASTP
14372431438184942thioredoxin-disulfide reductaseQuickGO ontologyBLASTP
14382191438539321thioredoxin family proteinQuickGO ontologyBLASTP
14386241438755132glycine reductase complex component A selenocysteine-containingQuickGO ontologyBLASTP
14387771439100324glycinesarcosinebetaine reductase complex component A1 Selenoprotein PA 1 Thioredoxinreductase complex A 1QuickGO ontologyBLASTP
143919514407331539glycine reductase complex component C beta subunitQuickGO ontologyBLASTP
144074914419151167glycine reductase complex component C alpha subunitQuickGO ontologyBLASTP
14424401443051612DNA-3-methyladenine glycosylaseQuickGO ontologyBLASTP
144311814453612244restriction endonuclease family proteinQuickGO ontologyBLASTP
1445791144700212125-methylthioribose kinaseQuickGO ontologyBLASTP
144714214481911050S-methyl-5-thioribose-1-phosphate isomeraseQuickGO ontologyBLASTP
144821514497051491ribose import ATP-binding protein RbsAQuickGO ontologyBLASTP
14497071450702996ribose transport system permease protein RbsCQuickGO ontologyBLASTP