Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:1146000 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
114614611483142169putative phage infection proteinQuickGO ontologyBLASTP
114852211506812160putative phage infection proteinQuickGO ontologyBLASTP
11516361152391756hypothetical proteinBLASTP
115263511547642130ATP-dependent DNA helicase RecQQuickGO ontologyBLASTP
11548751155306432ferritin-like diiron domain proteinQuickGO ontologyBLASTP
11555491156094546phosphodiesterase MJ0936 familyQuickGO ontologyBLASTP
11567321157115384response regulatorQuickGO ontologyBLASTP
115723011597042475KWG leptospira repeat proteinQuickGO ontologyBLASTP
116023411617571524L-lactate permeaseQuickGO ontologyBLASTP
116178611630601275hypothetical proteinBLASTP
11631031163891789electron transfer flavoprotein beta subunitFixA family proteinQuickGO ontologyBLASTP
116392311651251203electron transfer flavoprotein alpha subunitFixB family proteinQuickGO ontologyBLASTP
116518611665831398putative glycolate oxidaseQuickGO ontologyBLASTP
11668491167565717LytTr DNA-binding domain familyQuickGO ontologyBLASTP
116756911688491281hypothetical proteinBLASTP