Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:583870 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
583870584394525hypothetical proteinBLASTP
584396584986591methlytransferase homologQuickGO ontologyBLASTP
585072585311240hypothetical proteinBLASTP
585332585814483hypothetical proteinBLASTP
5864315876601230putative nuclease SbcCD D subunitQuickGO ontologyBLASTP
5876355911653531exonuclease SbcCQuickGO ontologyBLASTP
591193591741549hydrolase NUDIX familyQuickGO ontologyBLASTP
592570593421852hypothetical proteinBLASTP
593892594257366putative cadmium resistance transcriptional regulator CadCQuickGO ontologyBLASTP
5943335965612229cadmium-translocating P-type ATPaseQuickGO ontologyBLASTP
59698259705675tRNA-GluQuickGO ontology
5978915992671377PhoH family proteinQuickGO ontologyBLASTP
5995356005391005hypothetical proteinBLASTP
6005496015651017hypothetical proteinBLASTP