Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:3845942 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3845942384603291tRNA-LeuQuickGO ontology
38461733846577405putative general stress proteinQuickGO ontologyBLASTP
38466393846908270putative cell division protein FtsLQuickGO ontologyBLASTP
38470033847401399hypothetical proteinBLASTP
38474163847706291sporulation protein YabPQuickGO ontologyBLASTP
38478263848065240S4 domain proteinQuickGO ontologyBLASTP
38481393848417279DNA-binding protein HUQuickGO ontologyBLASTP
384854538499901446MazG family proteinQuickGO ontologyBLASTP
385000538515401536stage V sporulation protein BQuickGO ontologyBLASTP
38516733852224552stage V sporulation protein TQuickGO ontologyBLASTP
385242338534331011foldase proteinQuickGO ontologyBLASTP
385351738570233507transcription-repair coupling factorQuickGO ontologyBLASTP
38571813857750570peptidyl-tRNA hydrolaseQuickGO ontologyBLASTP
385786038590321173putative proteaseQuickGO ontologyBLASTP
385906738604761410sensor histidine kinaseQuickGO ontologyBLASTP
38604773861163687DNA-binding response regulatorQuickGO ontologyBLASTP
38613433862302960ribose-phosphate pyrophosphokinaseQuickGO ontologyBLASTP
386232338636961374UDP-N-acetylglucosamine pyrophosphorylaseQuickGO ontologyBLASTP
38638583864145288stage V sporulation protein GQuickGO ontologyBLASTP
38642483865063816pur operon repressorQuickGO ontologyBLASTP
386526338666391377UDP-N-acetylmuramate--alanine ligaseQuickGO ontologyBLASTP
3867090386716778tRNA-ProQuickGO ontologyBLASTP
386725938686081350Fe hydrogenaseQuickGO ontologyBLASTP