Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:3724312 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37243123724989678putative transaldolaseQuickGO ontologyBLASTP
37250083725655648haloacid dehalogenase IA family proteinQuickGO ontologyBLASTP
37256793726464786sorbitol-6-phosphate 2-dehydrogenaseQuickGO ontologyBLASTP
37264843726849366PTS system glucitolsorbitol-specific IIA componentQuickGO ontologyBLASTP
372706637280701005PTS system glucitolsorbitol-specific IIBC componentQuickGO ontologyBLASTP
37280833728628546PTS system glucitolsorbitol-specific IIC componentQuickGO ontologyBLASTP
37286713729066396glucitol operon activator proteinQuickGO ontologyBLASTP
372908037301291050putative L-iditol 2-dehydrogenaseQuickGO ontologyBLASTP
37301643731135972putative glucitol operon regulatorQuickGO ontologyBLASTP
373149137328401350phosphoglucosamine mutaseQuickGO ontologyBLASTP
373297537335055312-oxoacidacceptor oxidoreductase gamma subunit pyruvate2-ketoisovalerate familyQuickGO ontologyBLASTP
37335073734256750putative 2-oxoacidacceptor oxidoreductase beta subunitQuickGO ontologyBLASTP
373425637353261071putative 2-oxoacidacceptor oxidoreductase alpha subunitQuickGO ontologyBLASTP
37353423735551210putative 2-oxoacidacceptor oxidoreductase delta subunitQuickGO ontologyBLASTP
37356533736315663hypothetical proteinBLASTP
373657837376481071butyrate kinaseQuickGO ontologyBLASTP
37376773738588912phosphate butyryltransferaseQuickGO ontologyBLASTP
373858137396751095butyrate kinaseQuickGO ontologyBLASTP
373977637413741599oxidoreductase FAD-bindingQuickGO ontologyBLASTP
374137637426561281hypothetical proteinBLASTP
37426263743474849conserved hypothetical protein TIGR00159QuickGO ontologyBLASTP