Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:359310 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
359310360071762SIS domain proteinQuickGO ontologyBLASTP
360108360290183hypothetical protein
360559360756198cold shock proteinQuickGO ontologyBLASTP
361098361652555hypothetical proteinBLASTP
361942362055114hypothetical protein
362087362518432rrf2 family proteinQuickGO ontologyBLASTP
3626703632756062-hydroxychromene-2-carboxylate isomerase family proteinQuickGO ontologyBLASTP
363302363940639hypothetical proteinBLASTP
364378365139762putative transcriptional regulatorQuickGO ontologyBLASTP
3652583668411584PTS system glucosemaltose-specfic IIBC componentQuickGO ontologyBLASTP
3671073684411335maltose-6-phosphate glucosidaseQuickGO ontologyBLASTP
368454368927474PTS system glucosemaltose-specific IIA componentQuickGO ontologyBLASTP
3690653707801716dihydroxy-acid dehydrataseQuickGO ontologyBLASTP
3708323714796482-dehydro-3-deoxyphosphogluconate aldolase4-hydroxy-2-oxoglutarate aldolaseQuickGO ontologyBLASTP
3714813724851005putative 2-dehydro-3-deoxygluconokinaseQuickGO ontologyBLASTP
3726863745391854adenine deaminaseQuickGO ontologyBLASTP
374941375615675DNA-binding response regulatorQuickGO ontologyBLASTP
3756123770001389sensor histidine kinaseQuickGO ontologyBLASTP
377526378494969glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
378478378897420putative cell wall teichoic acid glycosylation protein GtcAQuickGO ontologyBLASTP
3790163812682253dolichyl-phosphate-mannose-protein mannosyltransferase family proteinQuickGO ontologyBLASTP
3816243826611038transcriptional regulator AraC familyQuickGO ontologyBLASTP