Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:3545017 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
354501735463691353glucose-6-phosphate isomeraseQuickGO ontologyBLASTP
35464533546623171hypothetical proteinBLASTP
35469543547598645transcriptional regulator TetR familyQuickGO ontology
35478293548362534acetyltransferase GNAT familyQuickGO ontologyBLASTP
354866335496671005D-lactate dehydrogenaseQuickGO ontologyBLASTP
35498593550854996D-lactate dehydrogenaseQuickGO ontologyBLASTP
355166935528351167hypothetical proteinBLASTP
355305135542471197electron transfer flavoprotein alpha subunitFixB family proteinQuickGO ontologyBLASTP
35542653555059795electron transfer flavoprotein beta subunitFixA family proteinQuickGO ontologyBLASTP
355507235562051134acyl-CoA dehydrogenase family proteinQuickGO ontologyBLASTP
355637235574961125R-phenyllactate dehydratase C subunitQuickGO ontologyBLASTP
355749835587211224R-phenyllactate dehydratase B subunitQuickGO ontologyBLASTP
35587263559520795R-phenyllactate dehydratase activatorQuickGO ontologyBLASTP
355952035607581239E-cinnamoyl-CoAR-phenyllactate CoA transferaseQuickGO ontologyBLASTP
356081335624441632AMP-binding enzymeQuickGO ontologyBLASTP
356291035642321323branched-chain amino acid transport system II carrier proteinQuickGO ontologyBLASTP
356469135662231533GMP synthaseQuickGO ontologyBLASTP
356623635676901455inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP