Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:3466000 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346624134673171077hypothetical proteinBLASTP
346739434684791086hypothetical proteinBLASTP
34686583468858201iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
34690953469988894hypothetical proteinBLASTP
346999134710881098putative R-2-hydroxyglutaryl-CoA dehydratase subunitQuickGO ontologyBLASTP
34710693472043975putative CoA-substrate-specific enzyme activaseQuickGO ontologyBLASTP
347210834737361629sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
347409434751011008electron transfer flavoprotein alpha subunitFixB family proteinQuickGO ontologyBLASTP
34751143475893780electron transfer flavoprotein beta subunitFixA family proteinQuickGO ontologyBLASTP
347590634770451140butyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
347723934784171179thiolaseQuickGO ontologyBLASTP
347844234792728313-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
347929234800747833-hydroxybutyryl-CoA dehydrataseQuickGO ontologyBLASTP
34804893480707219hypothetical proteinBLASTP
348075134818481098GIY-YIG domain proteinQuickGO ontologyBLASTP
348212434834161293xanthineuracil permease family proteinQuickGO ontologyBLASTP
34838193484715897HDIG domain proteinQuickGO ontologyBLASTP
34847843484936153hypothetical protein
34853243486088765prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
34862973486761465phosphodiesterase MJ0936 familyQuickGO ontologyBLASTP
34868043487169366hypothetical proteinBLASTP
34873003488049750glycerophosphoryl diester phosphodiesteraseQuickGO ontologyBLASTP