Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:3368951 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
336895133700271077TPR domain proteinQuickGO ontologyBLASTP
337017233718991728phosphoglucomutasephosphomannomutase family proteinQuickGO ontologyBLASTP
33728863373422537ribosomal 5S rRNA E-loop binding protein CtcL25TL5QuickGO ontologyBLASTP
337362933750891461OrnLysArg decarboxylaseQuickGO ontologyBLASTP
33752753376108834hypothetical proteinBLASTP
33763053377207903phosphate acetylbutyryl transferaseQuickGO ontologyBLASTP
337765833786711014dehydrogenase FMN-dependentQuickGO ontologyBLASTP
33789073379377471hypothetical proteinBLASTP
337956533819312367MutS2 family proteinQuickGO ontologyBLASTP
338206433844302367peptidase U32 familyQuickGO ontologyBLASTP
33851523386030879hypothetical proteinBLASTP
338623633880111776hypothetical proteinBLASTP
33881823388766585hypothetical proteinBLASTP
33888743389305432glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
33893273389917591hypothetical proteinBLASTP
339012233925032382phenylalanyl-tRNA synthetase beta subunitQuickGO ontologyBLASTP