Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2900057 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
290005729021622106glycosyltransferaseQuickGO ontologyBLASTP
29024942903324831flagellinQuickGO ontologyBLASTP
29036232903964342hypothetical proteinBLASTP
290397329064352463flagellar hook-associated proteinQuickGO ontologyBLASTP
29064572906843387flagellar protein FliSQuickGO ontologyBLASTP
29068802907179300hypothetical proteinBLASTP
29072372907593357flaG family proteinQuickGO ontologyBLASTP
29076092907827219carbon storage regulatorQuickGO ontologyBLASTP
29078272908258432hypothetical proteinBLASTP
29083262909288963flagellar hook-associated protein 3QuickGO ontologyBLASTP
290930629111711866flagellar hook-associated protein FlgKQuickGO ontologyBLASTP
29114532911857405flgN family proteinQuickGO ontologyBLASTP
29118572912138282regulator of flagellin synthesis FlgMQuickGO ontologyBLASTP
291272829138881161flagellar motor switch protein FliNQuickGO ontologyBLASTP
29138812914876996flagellar motor switch protein FliMQuickGO ontologyBLASTP
29149042915299396putative chemotaxis protein CheWQuickGO ontologyBLASTP
29153992915758360chemotaxis protein CheYQuickGO ontologyBLASTP
29157862916385600chemotaxis protein CheCQuickGO ontologyBLASTP
291661529184861872chemotaxis protein CheAQuickGO ontologyBLASTP
29184992919269771chemotaxis protein methyltransferase CheRQuickGO ontologyBLASTP
291928429203481065protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
29203712920859489chemotaxis protein CheDQuickGO ontologyBLASTP
29208762921322447chemotaxis protein CheWQuickGO ontologyBLASTP
292133829233712034hypothetical proteinBLASTP
292362429255791956PTS system glucose family IIABC componentQuickGO ontologyBLASTP