Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2877407 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28774072877976570dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
287798828790431056dTDP-glucose 46-dehydrataseQuickGO ontologyBLASTP
28790622879958897dTDP-4-dehydrorhamnose reductaseQuickGO ontologyBLASTP
28799602880880921glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
288133128824371107spore coat polysaccharide biosynthesis protein SpsCQuickGO ontologyBLASTP
28824632883455993UDP-glucose 4-epimeraseQuickGO ontologyBLASTP
28835112884173663putative methyltransferase type 11QuickGO ontologyBLASTP
288420128852291029hypothetical proteinBLASTP
288575528869001146putative carbamoyl-phosphate synthase large chainQuickGO ontologyBLASTP
288691828879701053hypothetical proteinBLASTP
288796728889711005N-acylneuraminate-9-phosphate synthaseQuickGO ontologyBLASTP
288897628901271152UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
28901412890806666LmbE family proteinQuickGO ontologyBLASTP
28908062891693888bifunctional polymyxin resistance protein ArnAQuickGO ontologyBLASTP
28916902892400711acylneuraminate cytidylyltransferaseQuickGO ontologyBLASTP
289239028934661077nucleotidyl transferaseQuickGO ontologyBLASTP
289349128963222832glycosyl transferase group 2 familyQuickGO ontologyBLASTP
289631528984532139glycosyltransferaseQuickGO ontologyBLASTP