Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2594159 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
259415925952351077hypothetical proteinBLASTP
25954412595647207hypothetical proteinBLASTP
259577925972241446amino acid permease family proteinQuickGO ontologyBLASTP
25973592598246888hypothetical proteinBLASTP
259881625998231008proline racemaseQuickGO ontologyBLASTP
25998372600307471PrdE proteinQuickGO ontologyBLASTP
26003212601097777PrdD proteinQuickGO ontologyBLASTP
26014382602163726D-proline reductase PrdB subunit selenocysteine-containingQuickGO ontologyBLASTP
26022392602514276hypothetical proteinBLASTP
260252326046312109putative D-proline reductase PrdA proproteinQuickGO ontologyBLASTP
26046562604832177hypothetical proteinBLASTP
260485426059721119putative electron transport proteinQuickGO ontologyBLASTP
26066132607275663hypothetical proteinBLASTP
260731526086191305putative electron transport proteinQuickGO ontologyBLASTP
26086182608734117hypothetical proteinBLASTP
26092112609738528hypothetical proteinBLASTP
26097432610222480hypothetical proteinBLASTP
26106992611127429PrdA domain proteinQuickGO ontologyBLASTP
261115826124681311putative electron transport proteinQuickGO ontologyBLASTP
261264426143981755sensory box sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
261473426159631230hypothetical proteinBLASTP