Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2374000 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23741422375041900hypothetical proteinBLASTP
237538223767041323proton-linked D-serineD-alanineglycine symporterQuickGO ontologyBLASTP
23767722377506735protein kinase domain proteinQuickGO ontologyBLASTP
237800923787827742-hydroxyglutaryl-CoA dehydratase component AQuickGO ontologyBLASTP
237887223803861515hypothetical proteinBLASTP
238068723817361050electron transfer flavoprotein alpha subunitFixB family proteinQuickGO ontologyBLASTP
23817552382540786electron transfer flavoprotein beta subunitFixA family proteinQuickGO ontologyBLASTP
238257923837121134acyl-CoA dehydrogenase family proteinQuickGO ontologyBLASTP
238421123853381128putative R-2-hydroxyglutaryl-CoA dehydratase beta subunitQuickGO ontologyBLASTP
238533823865701233putative R-2-hydroxyglutaryl-CoA dehydratase alpha subunitQuickGO ontologyBLASTP
238663323878471215putative hydroxyacyl-CoAR-2-hydroxyglutaryl-CoA transferaseQuickGO ontologyBLASTP
23883092388446138hypothetical protein
23884352389256822iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
238981623910871272putative R-2-hydroxyglutaryl-CoA dehydratase subunitQuickGO ontologyBLASTP
239109023927841695putative R-2-hydroxyglutaryl-CoA dehydratase subunitputative R-2-hydroxyglutaryl-CoA dehydratase activaseQuickGO ontologyBLASTP
239308323942341152putative methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
23948362395435600hypothetical proteinBLASTP
23958252396814990linear amide C-N hydrolase choloylglycine hydrolase familyQuickGO ontologyBLASTP