Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2328288 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
232828823300211734hypothetical proteinBLASTP
23300442330688645hypothetical protein
23307412330932192hypothetical proteinBLASTP
23311952331611417hypothetical proteinBLASTP
23317312332210480possible sigma factorQuickGO ontologyBLASTP
23325172332696180hypothetical proteinBLASTP
233272623345911866phage primase P4 familyQuickGO ontologyBLASTP
233461823363031686C-5 cytosine-specific DNA methylaseQuickGO ontologyBLASTP
233640823381021695phage DNA polymeraseQuickGO ontologyBLASTP
23381132338271159hypothetical protein
23383242338782459hypothetical proteinBLASTP
23387852339066282hypothetical protein
233906623407721707phage NTP-binding proteinQuickGO ontologyBLASTP
23407842340957174hypothetical protein
23409632341766804hypothetical proteinBLASTP
23417592342088330hypothetical proteinBLASTP
23420932342389297holliday junction resolvase HjcQuickGO ontologyBLASTP
23423892343216828hypothetical proteinBLASTP
23432092343655447hypothetical protein
234365923447561098phage helicaseQuickGO ontologyBLASTP
23448092344925117hypothetical protein
23449162345086171hypothetical proteinBLASTP
23451012345394294hypothetical proteinBLASTP
23454142346163750putative antirepressorQuickGO ontology
23461802346509330hypothetical protein
23465322346756225hypothetical protein
23469782347427450transcriptional regulatorQuickGO ontologyBLASTP
23474772347893417hypothetical proteinBLASTP
23482342348347114hypothetical protein
234845223495161065site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
2350254235225119982-enoate reductaseQuickGO ontologyBLASTP