Pre_GI Gene

Some Help

Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2093901 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20939012094896996putative internalinQuickGO ontologyBLASTP
209491820970052088carbohydrate binding proteinQuickGO ontologyBLASTP
209716720992572091sigma-54 dependent transcriptional regulatorQuickGO ontologyBLASTP
20996212099875255hypothetical proteinBLASTP
20998882100256369putative endoribonuclease L-PSPQuickGO ontologyBLASTP
210029821015931296sodiumdicarboxylate symporter family proteinQuickGO ontologyBLASTP
210161521027841170aminotransferase classes I and IIQuickGO ontologyBLASTP
210309821043901293hypothetical proteinBLASTP
21047302105716987putative internalinQuickGO ontologyBLASTP
210573721079562220hypothetical proteinBLASTP
210815721095961440sensor histidine kinaseQuickGO ontologyBLASTP
21095862110251666DNA-binding response regulatorQuickGO ontologyBLASTP
21105652111380816putative protein of unknown functionQuickGO ontologyBLASTP
21114062112161756putative ABC transporter permease proteinQuickGO ontologyBLASTP