Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:2064027 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
206216820640301863ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
206402720663272301putative ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
20667432067186444transcriptional regulator MarR familyQuickGO ontologyBLASTP
20672992067739441sperminespermidine acetyltransferaseQuickGO ontologyBLASTP
20679682068651684molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
20686532068880228molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
206916320709801818aldehyde ferredoxin oxidoreductase tungsten-containingQuickGO ontologyBLASTP
207139920732941896aor transcriptional regulatorQuickGO ontologyBLASTP
20733442073784441MOSC domain proteinQuickGO ontologyBLASTP
20737862074265480molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
20742692075228960molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
207528720771911905molybdopterin biosynthesis enzyme MoeA putative molybdate binding domainQuickGO ontologyBLASTP
207720320784291227molybdopterin biosynthesis enzyme MoeAQuickGO ontologyBLASTP
20784532078941489molybdopterin biosynthesis enzyme MogQuickGO ontologyBLASTP
20791432079835693tungstate ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
20798322080503672tungstate ABC transporter permease proteinQuickGO ontologyBLASTP
20805122081363852tungstate ABC transporter tungstate-binding proteinQuickGO ontologyBLASTP
208158320829051323MATE efflux family proteinQuickGO ontologyBLASTP
20829052083102198hypothetical proteinBLASTP
20833442083988645hypothetical proteinBLASTP
20843102084981672ABC transporter ATP-binding proteinQuickGO ontologyBLASTP