Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:1382000 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13823851382642258hypothetical proteinBLASTP
13829121383658747putative lipoproteinQuickGO ontologyBLASTP
13839771384204228rubredoxinQuickGO ontologyBLASTP
138423613856961461putative glyceraldehyde-3-phosphate dehydrogenase NADP-dependentQuickGO ontologyBLASTP
13857361386677942putative thioredoxin reductaseQuickGO ontologyBLASTP
13874621387839378GrdX proteinQuickGO ontologyBLASTP
138793013892161287glycine reductase complex component B alpha and beta subunitsQuickGO ontologyBLASTP
138924913905501302glycine reductase complex component B gamma subunit selenocysteine-containingQuickGO ontologyBLASTP
13907151391656942thioredoxin-disulfide reductaseQuickGO ontologyBLASTP
13916901392010321thioredoxin family proteinQuickGO ontologyBLASTP
13920961392227132glycinesarcosinebetaine reductase complex component A1 Selenoprotein PA 1 Thioredoxinreductase complex A 1QuickGO ontologyBLASTP
13922431392572330glycine reductase complex component A selenocysteine-containingQuickGO ontologyBLASTP
139266713942051539glycine reductase complex component C beta subunitQuickGO ontologyBLASTP
139422113953871167glycine reductase complex component C alpha subunitQuickGO ontologyBLASTP
13958141396425612DNA-3-methyladenine glycosylaseQuickGO ontologyBLASTP
139649113987162226restriction endonuclease family proteinQuickGO ontologyBLASTP
1399153140036412125-methylthioribose kinaseQuickGO ontologyBLASTP
140050414015531050S-methyl-5-thioribose-1-phosphate isomeraseQuickGO ontologyBLASTP
14017041402351648aldolase class II AraDFucA subfamilyQuickGO ontologyBLASTP
14025251403319795transcriptional regulator DeoR familyQuickGO ontologyBLASTP
14036261403985360hypothetical proteinBLASTP