Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:127000 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
127095127733639putative zinc-dependent hydrolaseQuickGO ontologyBLASTP
1281751312913117isoleucyl-tRNA synthetaseQuickGO ontologyBLASTP
131442132440999transcriptional regulator LacI familyQuickGO ontologyBLASTP
1326561367084053hypothetical proteinBLASTP
1367831378501068putative mannose-1-phosphate guanylyltransferasemannose-6-phosphate isomeraseQuickGO ontologyBLASTP
1381861394871302hypothetical proteinBLASTP
139492140298807conserved hypothetical protein TIGR00268QuickGO ontologyBLASTP
140318141064747hypothetical proteinBLASTP
1412891426711383radical SAM domain proteinQuickGO ontologyBLASTP
1428581441321275putative sugar-binding proteinQuickGO ontologyBLASTP
1442341453491116putative mannosyltransferaseQuickGO ontologyBLASTP
1455151465251011putative spore coat proteinQuickGO ontologyBLASTP
146540146734195hypothetical proteinBLASTP
146761147528768hypothetical proteinBLASTP
1475411485541014putative spore coat proteinQuickGO ontologyBLASTP
1489081500351128glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
1501521511561005spore coat protein CotSQuickGO ontologyBLASTP