Pre_GI Gene

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Host: NC_010516 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010516:1 Clostridium botulinum B1 str. Okra, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3813751338chromosomal replication initiator protein DnaAQuickGO ontologyBLASTP
163827411104DNA polymerase III beta chainQuickGO ontologyBLASTP
27602966207S4 domain proteinQuickGO ontologyBLASTP
303541291095DNA replication and repair protein RecFQuickGO ontologyBLASTP
41504413264hypothetical proteinBLASTP
443163441914DNA gyrase B subunitQuickGO ontologyBLASTP
637089552586DNA gyrase A subunitQuickGO ontologyBLASTP
937110872150216S ribosomal RNAQuickGO ontologyBLASTP
1103213933290223S ribosomal RNAQuickGO ontologyBLASTP
14026141421175S ribosomal RNAQuickGO ontologyBLASTP
1404114160120hypothetical proteinBLASTP
141501422879tRNA-MetQuickGO ontologyBLASTP
142301430778tRNA-AlaQuickGO ontologyBLASTP
1447114923453hypothetical proteinBLASTP
1493915460522putative transcriptional regulatorQuickGO ontologyBLASTP
15462166251164iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
16630193112682hypothetical proteinBLASTP