Pre_GI Gene

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Host: NC_010418 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010418:70000 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7009370983891hypothetical protein
7102571555531hypothetical protein
7162672045420hypothetical protein
7223372436204putative ABC transporter substrate-binding lipoproteinQuickGO ontology
7279773531735hypothetical proteinBLASTP
7354274075534hypothetical protein
7443975134696hypothetical protein
7527875724447hypothetical protein
7577076315546hypothetical protein
7652676828303hypothetical protein
7686877068201hypothetical protein
7718277754573hypothetical protein
7777177995225hypothetical protein
7820278564363hypothetical protein
7864379407765hypothetical proteinBLASTP
7947679922447hypothetical protein
7995680321366hypothetical proteinBLASTP
80462822851824reverse transcriptaseendonuclease proteinQuickGO ontologyBLASTP
8288883163276hypothetical protein
8322283371150hypothetical protein
8342483861438phage proteinQuickGO ontologyBLASTP
8392384195273hypothetical proteinBLASTP
8424684605360hypothetical protein
8472485422699hypothetical proteinBLASTP
8547585645171hypothetical protein
8578685965180hypothetical proteinBLASTP
8677887272495hypothetical protein
8729587498204hypothetical protein
8758188039459hypothetical protein
8811188434324hypothetical protein
8853888768231hypothetical protein
8913889305168hypothetical proteinBLASTP
8933090019690hypothetical proteinBLASTP
9017490776603single-strand binding proteinQuickGO ontologyBLASTP
90876920211146DNA polymerase III beta subunitQuickGO ontologyBLASTP