Pre_GI Gene

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Host: NC_010418 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010418:138325 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1383251397401416DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
139824140051228hypothetical proteinBLASTP
140066140209144hypothetical proteinBLASTP
140259141242984DNA polymerase III delta subunitQuickGO ontologyBLASTP
141261141821561hypothetical proteinBLASTP
141967142158192hypothetical proteinBLASTP
142759142875117hypothetical protein
1430661443881323hypothetical proteinBLASTP
144656144877222hypothetical proteinBLASTP
145006145197192hypothetical proteinBLASTP
145399145599201hypothetical protein
145654145812159hypothetical protein
145862146032171hypothetical protein
146108146371264hypothetical proteinBLASTP
146421146609189PhnB proteinQuickGO ontologyBLASTP
146799147038240hypothetical proteinBLASTP
147202147315114hypothetical proteinBLASTP
147405147974570hypothetical protein
148086148283198hypothetical protein
148423148782360hypothetical proteinBLASTP
148896149171276hypothetical proteinBLASTP
149422149583162hypothetical proteinBLASTP
149564149917354hypothetical proteinBLASTP
149937150572636conserved phage proteinQuickGO ontologyBLASTP
1509041524331530tetratricopeptide repeat domain proteinQuickGO ontologyBLASTP
1525441539531410HD domain proteinQuickGO ontologyBLASTP
154096154233138hypothetical protein
154295154888594putative guanylate kinaseQuickGO ontologyBLASTP
154909155136228hypothetical proteinBLASTP
155521156174654hypothetical protein
156234156989756hypothetical proteinBLASTP
157169157291123hypothetical protein
1575091585761068DNA modification methylaseQuickGO ontologyBLASTP
1586941601181425DNA primaseQuickGO ontologyBLASTP
160398160790393hypothetical proteinBLASTP
160792161004213hypothetical proteinBLASTP
161192161509318hypothetical proteinBLASTP
161763162200438phage proteinQuickGO ontologyBLASTP
162261162533273hypothetical proteinBLASTP
162616162897282hypothetical proteinBLASTP
162976163323348hypothetical proteinBLASTP
163529163828300putative sodiumalanine symporter family proteinQuickGO ontologyBLASTP
164342164539198hypothetical proteinBLASTP
164660165124465hypothetical proteinBLASTP
165363165839477hypothetical proteinBLASTP
165926166780855modification methylaseQuickGO ontologyBLASTP