Pre_GI Gene

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Host: NC_010379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010379:73718 Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7371874041324hypothetical proteinBLASTP
7406674329264hypothetical proteinBLASTP
7435774578222hypothetical proteinBLASTP
7457874784207hypothetical protein
7480475298495hypothetical proteinBLASTP
7540975573165hypothetical proteinBLASTP
7576276115354hypothetical proteinBLASTP
7618176561381death-on-curing family proteinQuickGO ontologyBLASTP
7655576728174hypothetical proteinBLASTP
76907782651359putative Cpp50QuickGO ontologyBLASTP
7845679142687hypothetical protein
7920279732531hypothetical proteinBLASTP
7987280438567hypothetical protein
8053080889360putative lipoproteinQuickGO ontology
8113481574441hypothetical proteinBLASTP
8167881887210hypothetical protein
8205182365315hypothetical proteinBLASTP
8243582851417hypothetical proteinBLASTP
8292583125201hypothetical protein
8318083359180hypothetical protein
8341383706294hypothetical proteinBLASTP
8386984063195hypothetical proteinBLASTP
8407884296219hypothetical proteinBLASTP
8436884589222hypothetical proteinBLASTP
8474484917174hypothetical protein
85097861311035hypothetical proteinBLASTP
8622786988762hypothetical proteinBLASTP
8702487758735hypothetical proteinBLASTP
87926900192094DNA helicase IIQuickGO ontologyBLASTP
9001690369354hypothetical protein
9074591416672thermonuclease TNase Micrococcal nucleaseStaphylococcal nucleaseQuickGO ontologyBLASTP
9153991841303hypothetical protein
9222392399177hypothetical protein
9245092737288hypothetical protein
93060942351176hypothetical proteinBLASTP
9445594802348hypothetical protein
9482595082258hypothetical protein
9520495419216hypothetical protein
9552395981459hypothetical protein