Pre_GI Gene

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Host: NC_010379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010379:6880 Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
68807020141hypothetical proteinBLASTP
71107565456hypothetical proteinBLASTP
76978287591metal dependent phosphohydrolaseQuickGO ontologyBLASTP
841798351419DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
991910134216hypothetical proteinBLASTP
1014910292144hypothetical protein
1034211325984DNA polymerase III delta subunit superfamilyQuickGO ontologyBLASTP
1134411904561hypothetical proteinBLASTP
1203612644609hypothetical proteinBLASTP
1282013377558hypothetical proteinBLASTP
1350613697192hypothetical proteinBLASTP
1380814068261hypothetical proteinBLASTP
1415714420264hypothetical proteinBLASTP
1447014658189PhnB proteinQuickGO ontologyBLASTP
1484915088240hypothetical proteinBLASTP
1516015498339hypothetical protein
1556715926360hypothetical proteinBLASTP
1604016315276hypothetical proteinBLASTP
1651416693180hypothetical proteinBLASTP
1674617099354hypothetical proteinBLASTP
1711917754636conserved phage proteinQuickGO ontologyBLASTP
18086196361551tetratricopeptide repeat domain proteinQuickGO ontologyBLASTP
19726211351410HD domain proteinQuickGO ontologyBLASTP
2147822071594putative guanylate kinaseQuickGO ontologyBLASTP
2209222319228hypothetical proteinBLASTP
2282223577756hypothetical proteinBLASTP
2375323875123hypothetical protein
2413624906771DNA modification methylaseQuickGO ontologyBLASTP
25024264481425DNA primaseQuickGO ontologyBLASTP
2672827120393hypothetical proteinBLASTP
2712227334213hypothetical proteinBLASTP
2752827845318hypothetical proteinBLASTP
2810628366261hypothetical proteinBLASTP
2843528887453hypothetical proteinBLASTP
2891629581666Upf868QuickGO ontologyBLASTP
2966429945282hypothetical proteinBLASTP
3002430371348hypothetical proteinBLASTP
3057730876300putative sodiumalanine symporter family proteinQuickGO ontologyBLASTP
3139031587198hypothetical proteinBLASTP
3170832172465hypothetical proteinBLASTP
3219332354162hypothetical protein
3241132887477hypothetical proteinBLASTP
3297433828855C-5 cytosine-specific DNA methylaseQuickGO ontologyBLASTP
3383333997165hypothetical protein
3426735082816hypothetical proteinBLASTP
3516835539372hypothetical protein
3568836596909hypothetical protein
3679937014216hypothetical protein
3710137391291hypothetical proteinBLASTP
3741937595177hypothetical protein
3760638226621ATPaseQuickGO ontologyBLASTP
3828439048765DNA methylaseQuickGO ontologyBLASTP
3907939537459hypothetical proteinBLASTP
3960939965357hypothetical protein
4002640211186hypothetical protein
4022840395168hypothetical protein
4043140643213hypothetical protein
42317461923876botulinum neurotoxin type B BoNTBQuickGO ontology