Pre_GI Gene

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Host: NC_010379 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010379:110760 Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1107601141823423putative viral A-type inclusion proteinQuickGO ontologyBLASTP
114274114942669hypothetical protein
1149451178632919hypothetical proteinBLASTP
1181411213323192hypothetical proteinBLASTP
121605122465861hypothetical proteinBLASTP
1226391236821044hypothetical proteinBLASTP
123778124572795hypothetical proteinBLASTP
124610125359750hypothetical proteinBLASTP
125591125761171hypothetical protein
126150126551402hypothetical protein
1265481289502403hypothetical proteinBLASTP
129132129731600hypothetical protein
129975130376402hypothetical protein
130538130681144hypothetical protein
130803130970168hypothetical protein
130970131335366hypothetical protein
131352131531180hypothetical protein
131556131726171hypothetical protein
131723131914192hypothetical protein
132248132553306hypothetical proteinBLASTP
132864133136273hypothetical protein
1333261354372112phosphoadenosine phosphosulfate reductase family proteinQuickGO ontologyBLASTP