Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:596034 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5960345986102577cell division transmembrane protein FtsKQuickGO ontologyBLASTP
6001386018261689hypothetical proteinBLASTP
601845602255411hypothetical proteinBLASTP
6035236046051083dihydroorotate dehydrogenase 2QuickGO ontologyBLASTP
60475860483477tRNA-HisQuickGO ontology
605381605707327hypothetical protein
605796606707912hypothetical proteinBLASTP
606809607720912hypothetical proteinBLASTP
608009608842834hypothetical proteinBLASTP
608835609722888hypothetical protein
609725610639915hypothetical proteinBLASTP
611094611495402hypothetical protein
611485612000516hypothetical protein
6142706154901221hypothetical proteinBLASTP
616128616907780hypothetical proteinBLASTP
6186216197481128major facilitator superfamily permeaseQuickGO ontologyBLASTP