Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:432000 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
433469433726258DNA-damage-inducible proteinQuickGO ontologyBLASTP
434103434453351helicase domain-containing proteinQuickGO ontologyBLASTP
4350744368371764hypothetical proteinBLASTP
4369284444697542filamentous hemagglutininQuickGO ontologyBLASTP
444534445124591hypothetical proteinBLASTP
445366446079714hypothetical proteinBLASTP
446073446747675hypothetical proteinBLASTP
446782447246465hypothetical proteinBLASTP
447352447837486hypothetical proteinBLASTP
447834448412579hypothetical proteinBLASTP
448465449046582hypothetical proteinBLASTP
4492884505261239hypothetical proteinBLASTP
450726451307582hypothetical proteinBLASTP
451360451950591hypothetical proteinBLASTP
4520474546112565hypothetical proteinBLASTP
454792455592801hypothetical proteinBLASTP
455554456534981helicase domain-containing proteinQuickGO ontologyBLASTP
4573104590971788hemolysin activation protein precursorQuickGO ontologyBLASTP
4591234672138091filamentous hemagglutininQuickGO ontologyBLASTP
467210467617408hypothetical proteinBLASTP
4676944690821389filamentous hemagglutininQuickGO ontologyBLASTP
469079469492414hypothetical proteinBLASTP
4695694709571389filamentous hemagglutininQuickGO ontologyBLASTP
470978471385408hypothetical proteinBLASTP
4714624728501389filamentous hemagglutininQuickGO ontologyBLASTP
472847473260414hypothetical proteinBLASTP
474780475193414hypothetical proteinBLASTP