Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2155500 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21556742156012339transcriptional regulatorQuickGO ontologyBLASTP
215651521578101296UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
21579782158130153hypothetical proteinBLASTP
2158311215838575tRNA-ThrQuickGO ontology
21642172165008792phage-related exonucleaseQuickGO ontologyBLASTP
21672192167407189hypothetical proteinBLASTP
21674102167799390hypothetical proteinBLASTP
21681132168430318hypothetical proteinBLASTP
216883121698981068hypothetical proteinBLASTP
217150121749113411hypothetical proteinBLASTP
21749172175555639hypothetical proteinBLASTP
21757202176043324hypothetical proteinBLASTP
21784502179028579hypothetical proteinBLASTP
21841062184417312hypothetical proteinBLASTP
21845492184872324hypothetical proteinBLASTP
218636721875181152hypothetical proteinBLASTP
21924702192985516hypothetical proteinBLASTP
21991052199281177hypothetical proteinBLASTP
21992972199644348hypothetical proteinBLASTP