Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2100500 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21017632102110348putative phenazine antibiotic biosynthesis proteinQuickGO ontologyBLASTP
21034812103873393transcriptional regulatorQuickGO ontologyBLASTP
210746121101212661ATP-dependent Clp protease atp-binding subunit ClpBQuickGO ontologyBLASTP
21133122113719408transcriptional regulatorQuickGO ontologyBLASTP
21150182115428411hypothetical protein
21167462116904159transcriptional regulatorQuickGO ontologyBLASTP
21172492117647399hypothetical proteinBLASTP
21176442117895252hypothetical proteinBLASTP
21186682119057390transcriptional regulatorQuickGO ontologyBLASTP
211929321205371245transporter putativeQuickGO ontologyBLASTP
21216372121792156hypothetical proteinBLASTP