Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:205500 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
205592206371780hypothetical proteinBLASTP
20807022317715108adhesinQuickGO ontologyBLASTP
223174223776603hypothetical proteinBLASTP
2247102260201311PpxGppA family exopolyphosphataseQuickGO ontologyBLASTP
226050226778729cell division protein ftsJQuickGO ontologyBLASTP
2269462279711026GTPase ObgEQuickGO ontologyBLASTP
2279732291121140gamma-glutamyl kinaseQuickGO ontologyBLASTP
2291572304131257hypothetical proteinBLASTP
230443231027585nicotinic acid mononucleotide adenylyltransferaseQuickGO ontologyBLASTP
231145231534390hypothetical proteinBLASTP
231536232018483hypothetical proteinBLASTP