Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1949637 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
19496371950062426hypothetical proteinBLASTP
19500781951043966hypothetical proteinBLASTP
19510561951397342hypothetical proteinBLASTP
195139419524431050hypothetical proteinBLASTP
195305519542601206hypothetical proteinBLASTP
195425319558301578phage proteinQuickGO ontologyBLASTP
195584319574651623phage proteinQuickGO ontologyBLASTP
19574581958039582phage proteinQuickGO ontologyBLASTP
19580021958358357phage related proteinQuickGO ontologyBLASTP
19583551958669315hypothetical proteinBLASTP
19588701959211342hypothetical proteinBLASTP
19592041959491288hypothetical proteinBLASTP
19594881960069582hypothetical proteinBLASTP
19601561960563408hypothetical proteinBLASTP
19605701961187618hypothetical proteinBLASTP
19612101961833624hypothetical proteinBLASTP
19618261962098273hypothetical proteinBLASTP
19620951962364270hypothetical proteinBLASTP
196236119633921032bacteriophage DNA transposition protein BQuickGO ontologyBLASTP
196375019657291980transposase class IIIQuickGO ontologyBLASTP
19657261966184459hypothetical proteinBLASTP
19661811967098918chromosome partitioning protein parBQuickGO ontologyBLASTP
19670411967439399hypothetical proteinBLASTP
19676341967939306hypothetical proteinBLASTP
19680691968620552hypothetical proteinBLASTP
19691101969931822phage-related modification methylaseQuickGO ontologyBLASTP
19700741971066993hypothetical proteinBLASTP
19710571971311255hypothetical proteinBLASTP
19713081971793486putative phage tail proteinQuickGO ontologyBLASTP
197195419729551002hypothetical proteinBLASTP
197320719767253519putative autotransporterQuickGO ontologyBLASTP
19771911977973783ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
19779601978844885oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
19788371979766930ABC transporter permease proteinQuickGO ontologyBLASTP
197976919808421074ABC transporter permease proteinQuickGO ontologyBLASTP