Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1914000 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
191449919171832685putative autotransporterQuickGO ontologyBLASTP
191835919215473189autotransporterQuickGO ontologyBLASTP
192221619287916576autotransporterQuickGO ontologyBLASTP
19290751930025951ferric anguibactin-binding proteinQuickGO ontologyBLASTP
19301251931081957ferric anguibactin-transport system permeaseQuickGO ontologyBLASTP
19310741932024951ferric anguibactin-transport system permeaseQuickGO ontologyBLASTP
19320211932779759ATPase component of iron transport systemQuickGO ontologyBLASTP
1932867193294074tRNA-GlnQuickGO ontology
19331071933928822phage-related modification methylaseQuickGO ontologyBLASTP
19340711935063993hypothetical proteinBLASTP
19350541935308255hypothetical proteinBLASTP
19353051935775471putative phage tail proteinQuickGO ontologyBLASTP
193593219382682337hypothetical proteinBLASTP