Pre_GI Gene

Some Help

Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1811000 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
181101518129311917VirD4 proteinQuickGO ontologyBLASTP
181454418161421599hypothetical proteinBLASTP
181645218180261575hypothetical proteinBLASTP
18183701819188819BepH proteinQuickGO ontologyBLASTP
181954118208331293hypothetical proteinBLASTP
182113818231051968hypothetical proteinBLASTP
182344118258132373BepI proteinQuickGO ontologyBLASTP
182666118282321572MviN proteinQuickGO ontologyBLASTP
182829418293641071tryptophanyl-tRNA synthetaseQuickGO ontologyBLASTP
18294281829919492universal stress family proteinQuickGO ontologyBLASTP
18299811830559579NifU-related proteinQuickGO ontologyBLASTP