Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1368500 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
136860713711712565hypothetical proteinBLASTP
137117513725331359hemagglutinin-like secreted proteinQuickGO ontologyBLASTP
13727741373343570hypothetical proteinBLASTP
137339313809707578filamentous hemagglutininQuickGO ontologyBLASTP
138106113828241764hemolysin activator precursorQuickGO ontologyBLASTP
13834451383795351helicase domain-containing proteinQuickGO ontologyBLASTP
1385017138510185tRNA-LeuQuickGO ontology
13852411385861621hypothetical proteinBLASTP
13859871386448462hypothetical proteinBLASTP
13864151386765351hypothetical proteinBLASTP
138687813888541977threonyl-tRNA synthetaseQuickGO ontologyBLASTP