Pre_GI Gene

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Host: NC_010117 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010117:980313 Coxiella burnetii RSA 331, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9803139816021290UDP-glucoseGDP-mannose dehydrogenase family proteinQuickGO ontologyBLASTP
9816059826091005capsular polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
9826149837711158glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
9837829848791098UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
9851109862521143glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
9862499881621914asparagine synthase glutamine-hydrolyzingQuickGO ontologyBLASTP
9881629894451284glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
9895909906901101glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
9909769924601485putative membrane proteinQuickGO ontologyBLASTP
992475993443969radical SAM domain proteinQuickGO ontologyBLASTP
993555993824270hypothetical proteinBLASTP
993833994714882putative methyltransferaseQuickGO ontologyBLASTP
9948329966371806ABC transporter permeaseATP-binding proteinQuickGO ontologyBLASTP
996648997199552putative acetyltransferaseQuickGO ontologyBLASTP
9972009990981899asparagine synthetase B glutamine-hydrolyzingQuickGO ontologyBLASTP